Herein, we provide evidence that uPAR expressing human ovarian cancer SKOV-3 cells are able to cross matrigel and interrupt monolayer integrity of mesothelial cells, the effects being reduced by antibodies recognizing the uPAR84-95 sequence or by the RERF peptide, which specifically inhibits uPAR84-95-triggered, FPR-mediated signals. Here, FPR1 is linked to ovarian cancer.