Further examination of gene expression patterns in normal and neoplastic tissue have indicated up-regulation of TEM-1 expression in tumor neovessels within human colorectal cancer [10], breast cancer [15, 16], histiocytomas [17] as well as expression directly on tumor cells of mesenchymal origin including sarcoma [18,19] and melanoma [20]. The gene discussed is CD248; the disease is colorectal cancer.