Since all TEM-1 associated biomarkers [TEM-1, HIF2α, CAIX, PDGFR-β, FN, Col I and Col IV] have shown putative expression in both tumor and stromal cellular compartments, we first examined total tissue level expression on the Colorectal Cancer (CRC) cohort, described in Table 1. The gene discussed is CA9; the disease is neoplasm.