TP53 and neoplasm: However, since siRNA cannot totally ablate expression of p53, further experiment with CRISPR-mediated p53 knockout cell line is our ongoing project to demonstrate the function of p53 in interaction between NUMB-1 and Aurora A. Of interest, we also found overexpression of NUMB-1 inhibits tumor growth in KYSE30 cell line and KYSE150 cell line, harboring mutant and wild type p53 respectively, which suggested the tumor suppressor function for NUMB-1 is p53 independent.