We have previously reported that there is a significant correlation between GLUT-1 and HIF-1α expression in laryngeal carcinoma [15], and there is further evidence thatthe phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathwaymay regulate HIF-1α and GLUT-1 [16]. This evidence concerns the gene AKT1 and laryngeal carcinoma.