These were rs1426654 in SLC24A5 and rs16891982 in SLC45A2, both associated with light skin pigmentation in individuals with European ancestry [7,27] and rs2814778 in DARC[28] (Figure 5a), which encodes the Duffy blood group antigen O allele and is associated with malaria resistance in Africans. Here, SLC24A5 is linked to malaria.