Cushing’s disease (CD), a rare illness characterized by chronic hypercortisolemia secondary to the overproduction of adrenocorticotropic hormone (ACTH) by a pituitary adenoma, is associated with high risk of developing serious complications such as diabetes mellitus, cardiovascular disease, and depression, and a mortality rate between 1.7- and 4.8-fold higher than that of the general population [1]. Here, POMC is linked to major depressive disorder.