We have recently described that hepatocyte-specific IKKγ/NEMO knockout (NEMOΔhepa) mice represent an excellent liver disease model as it reflects human liver pathogenesis with progression from chronic hepatitis to non-alcoholic steatohepatitis (NASH), liver fibrosis and finally HCC [5], [6]. The gene discussed is IKBKG; the disease is metabolic dysfunction-associated steatohepatitis.