Several genes comprising the network in Figure 2B have been previously implicated in the pathophysiology of RCC vasculogenesis and include ADM (adrenomedullin) [16], ANGPTL4 (angiopoietin-like 4) [17, 18], EGFR (epidermal growth factor receptor) [19, 20], EDNRA (endothelin receptor type A) [21], and LAMA4 (laminin, alpha 4) [22, 23]. The gene discussed is EDNRA; the disease is renal cell carcinoma.