Moreover, we implicate several of these gene hits not only in ccRCC for the first time (BHLHB3, CAMK1, CDH13, ENPP3, KCNJ2, KSR1, PLOD2, and TCF8), but also in a cancer model for the first time (CEP290, EFCAB3, PGBD5, RAPGEF5, SSPN, and TOX2). This evidence concerns the gene RAPGEF5 and cancer.