Real time quantitative PCR analysis (QPCR) confirmed over-expression of CAMK1, KISS1R, KSR1, SSPN, and CDH13 at the transcript level in patient derived stage I tumor tissue as compared to matched normal samples (Figure 3A), as expression of these hits appear to be transcriptionally upregulated in the gene array dataset in early stages of disease (Figure 1A). The gene discussed is SSPN; the disease is neoplasm.