Genes that are transcriptionally upregulated and have been previously linked to cell migration in RCC include LOXL2 (lysyl oxidase-like 2) [36], NNMT (nicotinamide N-methyltransferase) [37], NPTX2 (neuronal pentraxin 2) (data unpublished), and OLFML2A (olfactomedin-like 2A) [38]. The gene discussed is LOXL2; the disease is renal cell carcinoma.