AKT1 and cancer: Consistent with the findings from protein array, LTED cells constitutively activated several cancer-associated pathways, including the PI3K-AKT and ERK/MAPK pathways, which in turn activate the effectors, including S6, 4EBP1, YB1, β-catenin, cyclin B1 (P < 0.0001 respectively) and cyclin E1 (P = 0.037, Fig. 2F).