Meanwhile, lymph-node metastasis (hazard ratio: 2.204, 95% CI: 1.284–3.782, p = 0.004), tumoral PSPH positivity (hazard ratio: 2.068, 95% CI: 1.049–4.079, p = 0.036), stromal PSPH positivity (hazard ratio: 2.152, 95% CI: 1.107–4.184, p = 0.024), and stromal SHMT1 negativity (hazard ratio: 2.142, 95% CI: 1.219–3.764, p = 0.008) were associated with short OS. This evidence concerns the gene SHMT1 and metastatic malignant neoplasm in the lymph nodes.