TM6SF2 and hepatocellular carcinoma: It should, however, be noted that the NAFLD–HCC cohort contained only 99 patients and so, combined with a relatively modest TM6SF2 rs58542926 minor allele frequency, the current study had ~70% power to detect an effect if an additive genetic model and risk similar to that seen for fibrosis is assumed (α=0.05)32.