TM6SF2 rs58542926, but not NCAN rs2228603, was associated with severity of steatohepatitis in the discovery cohort by multivariate analysis adopting an additive model adjusted for gender, age at biopsy, BMI, T2DM and PNPLA3 rs738409 genotype (β=0.288±0.139, 95%CI 0.015–0.561; P=0.039). This evidence concerns the gene NCAN and type 2 diabetes mellitus.