In particular, a variant within the NCAN gene (rs2228603 C>T) that is in strong linkage disequilibrium (D′=0.926, r2=0.798) with TM6SF2 rs58542926 was reported to be associated with radiologically and histologically characterized NAFLD in both GWAS and candidate-gene studies9, 21. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.