RYR2 and catecholaminergic polymorphic ventricular tachycardia: Since its identification as the major candidate gene in autosomal-dominantly inherited forms of CPVT, more than 180 genetic variants, mostly missense mutations of the RyR2 gene have been attributed to arrhythmogenic disorders including CPVT1 (OMIM 604772) and ARVD2 (OMIM 600996) [6], [7].