The present study indicated downregulation of E-cadherin was significantly correlated with poor OS and DFS/PFS, additionally, downregulation of E-cadherin was associated with invasive phenotype (including grade of differentiation, lymph node metastasis, vascular invasion, and TNM stages) in NSCLC. The gene discussed is CDH1; the disease is metastatic malignant neoplasm in the lymph nodes.