CXCL12 and neoplasm: In fact, CAFs release a great number of pro-angiogenic factors including VEGF, CXCL12, FGF, IL-8/CXCL8 and PDGF-C in the ECM to recruit other stromal cell types such as endothelial cells and their precursors in order to stimulate tumor angiogenesis and vasculogenesis [54].