The role of MT1-MMP in prostate cancer metastasis was clearly demonstrated in a study by Bonfil et al. in which LNCaP cells overexpressing MT1-MMP produced larger tumors and more osteolysis in bone compared to control cells, whereas DU145 cells with MT1-MMP knockdown induced osteogenic changes only [135]. This evidence concerns the gene MMP14 and Familial prostate cancer.