MMP2 and Familial prostate cancer: Analysis of MMP mRNA and protein levels in the serum and tissue samples from prostate cancer patients has shown that increased expression of MMP-2, -3, -7, -9, -13, -14, -15 and -26 is correlated with advanced or metastatic disease, while MMP-1 expression is associated with lower grade tumors and a lower incidence of invasion (see Table 1 for a summary of literature).