Increased expression of MMP-2 has been extensively reported in prostate cancer [28,29,30,32,33,39,40,41,56] and higher MMP-2 expression has been correlated with larger tumor size, higher Gleason score and more advanced pathological TNM stage (a clinical cancer staging system used to describe the extent of a person’s cancer) [32,40,41,42]. This evidence concerns the gene MMP2 and Familial prostate cancer.