Activated MMP-7 mediates the cleavage of ECM and basement membrane proteins such as fibronectin, collagen type IV, laminin, and others, as well as mediates the ectodomain shedding of pro- and anti-tumor molecules such as tumor necrosis factor-α, Fas ligand, heparin-binding epidermal growth factor, E-cadherin and β4-integrin [105,106,107]. The gene discussed is MMP7; the disease is neoplasm.