Mechanistically, MT1-MMP not only played an essential role in bone matrix degradation, but also functioned as a sheddase to release RANKL, an osteoclastogenic factor, from the surface of osteoblasts and prostate cancer cells to enhance osteoclast differentiation and activate Src-dependent prostate cancer cell migration [136] (Figure 3). This evidence concerns the gene TNFSF11 and prostate carcinoma.