Mechanistically, it is proposed that MMP-7 secreted by both osteoclasts and tumor cells cleaves membrane bound receptor activator of NF-κB ligand (RANKL) on the osteoblast surface and the resulting soluble RANKL mediates the activation of osteoclasts at or near the tumor-bone interface, resulting in bone degradation [119] (Figure 3). Here, TNFSF11 is linked to neoplasm.