Henao-Mejia et al. [89] reported that inflammasome deficiency causes a pattern change of gut micropathogens followed by increased influx of TLR4 and TLR9 agonists into the portal circulation and exacerbation of hepatic inflammation and steatosis with TNF-α expression, leading to NASH progression. Here, TLR4 is linked to metabolic dysfunction-associated steatohepatitis.