Although MMP-2 involves angiogenesis in HCC [141], since Sato et al. [142] identified MT1-MMP and the activation mechanism of pro-MMP-2 by MT1-MMP and TIMP-2 on the cell surface was reported [143], there have been several papers investigating MMP-2, TIMP-2 and/or MT1-MMP in HCC [135,144,145,146,147,148,149,150,151,152,153,154]. Here, TIMP2 is linked to hepatocellular carcinoma.