PPARG and metabolic dysfunction-associated steatohepatitis: PPARγ maintains the quiescent state of HSC phenotype (reviewed in [47]), and PPARγ agonists such as pioglitazone and rosiglitazone recovered to the quiescent phenotype from myofibroblast-like cells of HSC followed by decrease in NASH fibrosis in experimental and clinical studies ([74,77,92], reviewed in [47]), although Belfort et al. [101] showed no decrease in NASH fibrosis, but some decrease in inflammation in liver.