Concerning MMP-9, Tarrats et al. [114] found that TNF receptor increased MMP-9, and Wanninger et al. [113] showed that the increased activity of MMP-9 was not induced by hepatic steatosis but by hepatic inflammation and fibrosis using a rodent model of non-alcoholic steatohepatitis. Here, MMP9 is linked to metabolic dysfunction-associated steatohepatitis.