For CD4+ TILs, the proinflammatory cytokines IL1β, IL-6, and IL-10 but not IL-4 were increased when stimulated with EXO1 or EXO2; however, only the increase in IL-6 (without NPC cells) reached statistical significance (P < 0.05). The gene discussed is CD4; the disease is nasopharyngeal carcinoma.