The presence of known exosome markers, including CD63, LAMP1, major histocompatibility complex class I (MHC-I) and class II (MHC-DR), and HSP70, and other immune-related markers, including EBV latent antigen LMP1 (EXO1), galectin-9 (a ligand of the membrane receptor Tim-3), chemokine receptor CXCR4, and membrane-bound TGF-β, were observed on isolated tumor-derived exosomes. The gene discussed is CXCR4; the disease is neoplasm.