Aur treatment for 12 h at dosesranging from 0.25 to 1.0 μM resulted in significant apoptosis in the monocytesfrom AML patients as detected with Annexin V/PI staining followed by flow cytometry(Figs. 8B) or by fluorescence microscopy (Fig.8D); however, similar treatment only causedminimal cell death in monocytes from healthy volunteers (Fig. 8C). The gene discussed is ANXA5; the disease is acute myeloid leukemia.