PI3K/Akt, HIF-1, c-Myc, p53, and AMPK pathways are intertwined with cancer cell glucose metabolism via affecting the activities or expression of metabolic enzymes and metabolites transporters [10-12], while Rho GTPase/NF-κB, c-Myc and miR-23a/b are implicated in regulating glutamine metabolism involving glutaminase and glutamine transporters [13, 14]. Here, MYC is linked to cancer.