In summary, our data establish a role of Gal-4 as tumor suppressor in PDAC, since we showed that elevated Gal-4 levels correlated significantly with reduced lymph node metastasis in PDAC patients, as well as with reduced in vitro migratory and invasive behavior in primary PDAC cultures, and reduced liver metastasis in mice. This evidence concerns the gene LGALS4 and neoplasm.