The genotypes of ACE I/D (DD/II, adjusted OR, 2.21; 95% CI, 1.01–4.83) and G2350A (GA/GG, adjusted OR, 1.93; 95% CI, 1.02–3.63; AA/GG, and adjusted OR, 2.41; 95% CI, 1.11–5.22) were also significantly different for patients with hypertensive nephropathy compared with controls. Here, ACE is linked to hypertensive nephropathy.