QPCR revealed that methylation and/or deletions considerably contribute to inactivation of the majority of examined genes (LRRN1, GORASP1, IQSEC1, FOXP1, GNAI2, FGD5, PLCL2, and ALDH1L1) in ccRCC. The gene discussed is GORASP1; the disease is nonpapillary renal cell carcinoma.