QPCR revealed that methylation and/or deletions considerably contribute to inactivation of the majority of examined genes (LRRN1, GORASP1, IQSEC1, FOXP1, GNAI2, FGD5, PLCL2, and ALDH1L1) in ccRCC. Here, FGD5 is linked to nonpapillary renal cell carcinoma.