Proteins encoded by the identified genes are involved in signaling pathways and biological processes frequently affected during development and progression of different cancer types, PRICKLE2 in WNT pathway; EPHB1 in Ephrin-EphR pathway; VHL and GORASP1 in apoptosis; CTDSPL (RBSP3) in cell cycle regulation; GNAI2 in transmembrane signaling systems; FGD5 in regulation of actin cytoskeleton; NKIRAS1 potent regulator of NFkappaB activity; and FOXP1 transcription factor, that are involved in tissue-specific expression [21, 22]. This evidence concerns the gene VHL and cancer.