Although in most studies serum TPO levels are decreased in liver cirrhosis, thrombocytopenia is correlated positively with TPO levels and platelet counts are increased after recovery of liver synthesis function; orthotopic liver transplantation; some studies have been reported that serum TPO concentrations are elevated or normal in thrombocytopenic cirrhosis patients, no correlation was determined between TPO levels and thrombocytopenia, and rather than TPO levels, decreased platelet counts are associated with other factors like splenic sequestration (6-20). The gene discussed is TPO; the disease is cirrhosis of liver.