Indeed, analysis of this breast cancer cohort at the Oncomine website (http://www.oncomine.org) revealed that OPG copy number gains occurred in the major invasive breast carcinoma subtypes present in the set (ductal, lobular, and mixed), and that OPG copy numbers were significantly higher than in normal breast tissue (Fig.1A). This evidence concerns the gene TNFRSF11B and breast cancer.