However, with regard to the heart, Arrb1 preferred to perform a G-protein dependent function, and regulates the majority of cardiovascular G protein-coupled receptors, especially adrenal and central sympathetic nervous system α2ARs, to perform a negative impact on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms [26]. Here, ARRB1 is linked to heart failure.