Moreover, steatosis can be influenced by altering the expression of key UPR mediators, including BiP (Ji et al., 2011; Kammoun et al., 2009; Ye et al., 2010), PERK (Teske et al., 2011), IRE1A/XBP1 (Lee et al., 2008; Ozcan et al., 2006; Zhang et al., 2011) and ATF6 (Cinaroglu et al., 2011; Howarth et al., 2014; Rutkowski et al., 2008; Wu et al., 2007; Yamamoto et al., 2010). This evidence concerns the gene ATF6 and steatosis.