TARDBP and amyotrophic lateral sclerosis: Mutations in TARDBP (Kabashi et al., 2008; Sreedharan et al., 2008) are responsible for ~3% of fALS and ~1.5% of sALS cases, and more than 40 mutations have been linked to ALS, the vast majority being located in the C-terminal glycine-rich region, which is responsible for protein-protein interactions that are as-yet unidentified (Lattante et al., 2013).