Combined with modeling of human LTA4H genotypes and dexamethasone treatment in zebrafish, further studies in human patients revealed that the survival effect of dexamethasone in TB meningitis associated strongly with the high-activity (and not the low-activity) LTA4H variant, suggesting that genotype-guided therapies might be useful in humans (Tobin et al., 2012). This evidence concerns the gene LTA4H and meningeal tuberculosis.