AKT1 and acute lymphoblastic leukemia: Approximately 50% of the evolved clones activated the Akt signaling pathway, which, although not previously linked to leukemia-propagating activity, is a known prognostic indicator in T-ALL patients and has been associated with dexamethasone resistance in human T-ALL cells (Gutierrez et al., 2009; Piovan et al., 2013).