APOE and atherosclerosis: These single-amino-acid variations inthe apoE sequence have serious effects on its properties, with apoE2 havingreduced binding affinity for the low density lipoprotein (LDL) receptor[5] and apoE4 exhibiting anintrinsic domain interaction that alters its lipid-binding properties andresults in an increased risk of hyperlipidemia and atherosclerosis[4].