In multivariate analysis CTC_EMT (p = 0.03) and tumor grade (p = 0.01) were independently associated with MMP1 expression in breast tumor cells, while Ki-67 (p = 0.0001) and CTC_EMT (p = 0.04) were independently associated with MMP1 expression in tumor associated stroma (Tables 3 and4). This evidence concerns the gene MKI67 and neoplasm.