GAK is also overexpressed in KHOS and U2OS osteosarcoma cells; its overexpression is associated with poor prognosis, and siRNA-mediated knockdown of GAK decreases the proliferation of osteosarcoma cells [31], suggesting that GAK plays a pivotal role in the control of the proliferation rate of osteosarcoma cells. The gene discussed is GAK; the disease is osteosarcoma.