Thus, polymorphisms associated with higher IL-6r and IL-6 levels (IL6R C>T (rs4537545)), higher TLR2 levels (TLR2 C>T (rs1816702)) and increased TNFRSF1A expression (TNFRSF1A −609 G>T (rs4149570)) were associated with increased risk of IBD. This evidence concerns the gene IL6 and inflammatory bowel disease.