Thus, polymorphisms associated with higher TLR2 levels (TLR2 C>T (rs1816702)), increased TNFRSF1A expression (TNFRSF1A −609 G>T (rs4149570)) and higher IL-6r and IL-6 levels (IL6R C>T (rs4537545)) were associated with increased risk of CD. This evidence concerns the gene TNFRSF1A and Cowden disease.