They contribute to the expression of angiogenic CXC chemokines via NF-κB activation in cancer cells, thus enhancing tumor-associated angiogenesis [61, 62] and suggesting for a potential role of 7TM-GPCRs, such as CXCR2, and PTKR in preneoplastic to neoplastic transformation. Here, NFKB1 is linked to neoplasm.