A parallel concept of how CsA might induce renal injury was described by Li and Yang, suggesting that kidney damage involves activation of the innate immune response that causes NF-κβ activation and induces dendritic cell maturation and T-lymphocyte infiltration into the graft, with both pathways ultimately resulting in interstitial inflammation and interstitial fibrosis that contributes to chronic nephropathy [47]. This evidence concerns the gene NFKB1 and Nephropathy.