XRCC1 and systemic lupus erythematosus: When the association between XRCC1 polymorphisms and SLE manifestations was analyzed, we found higher frequency of XRCC1 Arg399Gln Arg/Gln genotype in SLE patients with malar rash compared to SLE patients without this manifestation (OR = 0.42 (95% CI = 0.21–0.83); P = 0.01) (Table 4).