A reduction in the activity of the Akt pathway, as observed in different models of muscular atrophy, results in decreased levels of phosphorylated FoxO and consequent upregulation of atrophy related genes [14, 62], which are responsible for increased protein degradation through the ubiquitin-proteasome system [7, 63, 64]. This evidence concerns the gene AKT1 and muscular atrophy.