To clarify the role of CD44 rs187115 gene polymorphisms in the clinicopathologic status of HCC patients, the distribution frequency of clinical statuses and frequency of CD44 genotypes in HCC patients were estimated, including TNM clinical staging, primary tumor size, lymph node involvement, distant metastasis, hepatitis B surface antigen (HBsAg), antibody to HCV (anti-HCV), and liver cirrhosis. Here, CD44 is linked to hepatocellular carcinoma.