In fact, beside radiography, the progression of metastatic PCa is monitored by the product of collagen degradation, N-telopeptide (NTx) or C-telopeptide type I collagen (CTx), and cross-linked C-terminal telopeptides (ICTP) together with markers of bone formation, such as amino-terminal procollagen propeptides (PINP), osteocalcin, and bone-specific alkaline phosphatase (BALP) [6–8]. This evidence concerns the gene BGLAP and posterior cortical atrophy.