The family of ErbB receptors includes four members: ErbB1 (epidermal growth factor receptor, EGFR); ErbB2 (neuroblastoma or glioblastoma-derived, NEU; human epidermal growth factor receptor 2, HER2); ErbB3 (human epidermal growth factor receptor 3, HER3); ErbB4 (human epidermal growth factor receptor 4, HER4); however, only for EGFR and HER2 sufficient data have been accumulated for suggesting a role in bone metastasis. This evidence concerns the gene ERBB4 and neuroblastoma.