CLU and Alzheimer disease: The gene expression of apolipoprotein A and apolipoprotein B has been found to be regulated by zinc and copper (Zhang et al., 1995; Reaves et al., 2000; Cui et al., 2002) and more importantly, another AD-related apolipoprotein, clusterin (apolipoprotein J; Jones, 2010), is increased after zinc exposure (Trougakos et al., 2006).