On the other hand, whilst ApoE4 has been shown to not significantly interact with tau (Strittmatter et al., 1994), it does increase tau phosphorylation and accumulation in the neuronal soma and dendrites, facilitating the formation of NFTs during aging and AD progression (Harris et al., 2003; Brecht et al., 2004; Andrews-Zwilling et al., 2010). Here, APOE is linked to Alzheimer disease.