Hence, (1) memory requires restricted or selective cAMP production (Pérez-García and Meneses, 2008; Meneses, 2013); (2) a major and consistent emerging finding is that 5-HT7 receptor stimulation seems to facilitate memory formation and reverse memory impairment; (3) expression of 5-HT7 (and 5-HT1A) receptors are accompanying memory; (4) the 5-HT7 antagonism alone had no effect but reversed memory deficits. The gene discussed is HTR7; the disease is memory impairment.