TP53 and lung adenocarcinoma: In studies of human lung adenocarcinoma cells depleted of RPL24 by RNA interference, and in RPL24 haploinsufficient mouse embryonic fibroblasts (MEFs), RPL24 reduction is associated with increased p53 expression [9], suggesting that the prevention of tumorigenesis by reduced RPL24 may also depend on a p53-dependent checkpoint mechanism.