As shown in Table 1, in different age groups, no significant difference was detected no matter by nuclear, cytoplasmic or overall MTA1 analysis (P = 0.537, P = 0.302, and P = 0.178, respectively); However, in different groups of clinical stage, T stage and metastasis, the differences are all highly significant by nuclear, cytoplasmic and overall MTA1 analyses (P <0.01 for every test), indicating that both nuclear and cytoplasmic MTA1 were involved in tumor promotion; The role of MTA1 in cancer differentiation is poorly understood. The gene discussed is MTA1; the disease is cancer.