The TBL1XR1 mutation rate in our series and the recurrent deletions of 3q26.32 (TBL1XR1 locus) reported in PCNSL [7], extracerebral DLBCL [15], and acute lymphoblastic leukemia [27, 28] suggest its potential role as a tumor suppressor. This evidence concerns the gene TBL1XR1 and diffuse large B-cell lymphoma.