In addition, overexpression of GCIP in mouse liver suppressed diethylnitrosamine (DEN)-induced liver tumors in transgenic mice [27], and mice lacking GCIP (Maid) expression in the liver are prone to earlier development of hepatocellular carcinomas (HCCs) and hepatocellular adenomas (HCAs) [28]. Here, CCNDBP1 is linked to hepatocellular adenoma.