AKT1 and cancer: The factors activate the relative signaling pathways, such as the Ras/Raf/mitogen-extracellular activated protein kinase kinase (MEK)/ extracellular signal-regulated kinase (ERK), phosphatidylinositol-3-kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten (PTEN)/Akt/mammalian target of rapamycin (mTOR), that are involved in cancer cell survival via interactions with their specific receptors and then maintain the malignant growth of tumors [9].