AKT1 and colonic neoplasm: Our previous study showed that hSulf-1 is inactivated in majority of human cancers including hepatocellular, breast, gastric, renal and colon cancers, compared with their adjacent normal tissues, and reactivation of hSulf-1 can suppress cancer cell proliferation and xenograft tumor growth by inhibiting the activity of ERK and AKT signaling pathways [11,12].