Given that the hSulf-1-mediated decrease of Cyclin D1 and Survivin in HCC cancer cells, it is concluded that the molecular mechanism by which the hSulf-1 expression reverses the bFGF-mediated cell cycle progression and cell apoptosis inhibition may be through the modification of AKT- and ERK-regulated Cyclin D1 and Survivin signaling pathways. The gene discussed is CCND1; the disease is hepatocellular carcinoma.