Correspondingly, compared with the cells cultured in media containing bFGF, the percentages of G0/G1-phase and G2-phase were increased, the percentages of S-phase were decreased, and the percentages of apoptosis were increased in the Ad5-hSulf1-infected HCC cells (Fig. 1B-C). This evidence concerns the gene SULF1 and hepatocellular carcinoma.