AKT activation was observed in TRAIL-resistant cancer cells compared with sensitive cells (Fig. 7A) while there was no marked difference of other survival factors including such as mTOR, CFLAR(FLIP) and Bcl2, pro-apoptotic factor such as BAX, tumor suppressor PTEN and p38 in TRAIL-sensitive and resistant cancer cells (Fig. 7A). This evidence concerns the gene BCL2 and cancer.