CXCR4 and neoplasm: Therefore, our data indicates that CXCL8 signaling originating from PTEN-deficient tumor cells increases the expression of CCR2 and CXCR4 in prostate epithelium, but of potential significance, we observed that the expression of these receptors can be induced in prostate epithelial cells that still retain functional PTEN and have the capacity to respond to CXCL8.