Interestingly, CXCL8 signaling increased the expression of CXCR1 and CXCR2 receptors in PTEN-deficient prostate cancer cells, suggesting that CXCL8 signaling acts in a self-sustaining capacity, to potentiate its signaling in PTEN-deficient prostate cancer. This evidence concerns the gene CXCL8 and Familial prostate cancer.