Furthermore, CXCL8 signaling also increased the expression of CXCR4 and CXCR7 (the receptors mediating the biological activity of CXCL12) and CCR2 (a receptor activated by the ligand CCL2) in both PTEN-expressing and PTEN-deficient prostate cancer cells. The gene discussed is CXCL8; the disease is prostate carcinoma.