To explore the significance of CXCL8-promoted and stromal-derived chemokine signaling on prostate cancer cell-migration, we established a series of in vitro experiments to characterize the functional importance of CXCL8, CXCL12 and CCL2 as independent and co-dependent migratory factors within the prostate tumor microenvironment. This evidence concerns the gene CCL2 and Familial prostate cancer.