Mechanistically, we identify that the cap-dependent translation repressor 4E-BP1 functions as a key effector of mTROC1 activation on translational control of Snail expression and its subsequent activities as noted by the transcriptional repression of E-cadherin, induction of EMT and promotion of migration and invasion in colon and breast cancer cells (Figure 7). Here, SNAI1 is linked to breast carcinoma.