A recent report by Evdokimova and colleagues [24] suggested that YB-1 is positively involved in the regulation of Snail expression via cap-independent translation associated with breast cancer aggressiveness, as they showed that inhibition of mTORC1-mediated cap-dependent translation with rapamycin does not affect Snail levels in YB-1-expressing premalignant MCF10AT human mammary epithelial cells. This evidence concerns the gene YBX1 and breast cancer.