First, we showed that as compared with rapamycin, both mTOR kinase inhibitor AZD8055 and/or specific inhibition of mTORC1 by raptor knockdown exhibit potent inhibition of 4E-BP1 phosphorylation; and both also effectively repress Snail expression and its subsequent activities in colon and breast cancer cell lines with highly expressed YB-1 (Figure 3). Here, YBX1 is linked to breast carcinoma.