VDAC1 and renal cell carcinoma: If the high expression level of Nek1 accounts for stable Nek1-VDAC1 complexes detected in RCC cells treated with a high dose of genotoxic agents, then the downregulation of Nek1 expression to decrease the Nek1 in the cytosol in RCC cells might increase their respective sensitivity to genotoxic agents.