Immunohistochemistry analysis on formalin-fixed, paraffin-embedded tissue from 5 samples of stage I renal clear cell carcinoma showed that Nek1 expression is significantly increased in neoplastic cells compared to the adjacent normal renal tubular epithelial cells, which have very little Nek1 expression (Figure 2A). The gene discussed is NEK1; the disease is clear cell renal carcinoma.